Article

Effect of Parkinson's disease-related alpha-synuclein abnormalities on the maturation of distinct iPSC-derived neuronal populations

2017-01-01

Abstract excerpt

Parkinson’s disease (PD) is the second most common age-related neurodegenerative condition. It is neuropathologically characterised by the presence of Lewy pathology and the degeneration of the midbrain dopaminergic neurons from the substantia nigra pars compacta. Lewy pathology mainly consists of filamentous aggregated alpha-synuclein and familial forms of PD can be caused by genetic alternations in the SNCA gene...

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Literature Corpus work: 99cf28d6-f4a4-5f1e-8353-49b1eea653eb
DOI: 10.17863/cam.13638

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