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Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson's disease.

Stem cell research - 1 Sept 2023

Devito Liani G, Zanjani Zeinab Shadman, Evans James R, Scardamaglia Annarita, Houlden Henry, Gandhi Sonia, Healy Lyn

Abstract excerpt

Mutations or multiplications of the SNCA (Synuclein Alpha) gene cause rare autosomal dominant Parkinson's disease (PD). The SNCA G51D missense mutation is associated with a synucleinopathy that shares PD and multiple system atrophy (MSA) characteristics. We generated induced pluripotent stem cell (iPSC) lines from two individuals with SNCA G51D missense mutations at risk of PD. Dermal fibroblasts were...

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PMID: 37336145
DOI: 10.1016/j.scr.2023.103134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson's disease.PMID 37336145Read ↗

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