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Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease

20 Nov 2013

Abstract excerpt

iPSCs (induced pluripotent stem cells) are the newest tool used to model PD (Parkinson's disease). Fibroblasts from patients carrying pathogenic mutations that lead to PD have been reprogrammed into iPSCs, which can subsequently be differentiated into important cell types. Given the characteristic loss of dopaminergic neurons in the substantia nigra pars compacta of PD patients, iPSC-derived midbrain dopaminergic...

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PMID: 24256244
DOI: 10.1042/bst20130194

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