Article
Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.
Genes & development - 15 Nov 2007
Aggarwal Priya, Lessie Matthew D, Lin Douglas I, Pontano Laura, Gladden Andrew B, Nuskey Beth, Goradia Ami, Wasik Mariusz A, Klein-Szanto Andres J P, Rustgi Anil K, Bassing Craig H, Diehl J Alan
Abstract excerpt
Deregulation of cyclin D1 occurs in numerous human cancers through mutations, alternative splicing, and gene amplification. Although cancer-derived cyclin D1 mutants are potent oncogenes in vitro and in vivo, the mechanisms whereby they contribute to neoplasia are poorly understood. We now provide evidence derived from both mouse models and human cancer-derived cells revealing that nuclear accumulation of...
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