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A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response

17 Apr 2017

Abstract excerpt

The human Mediator complex regulates RNA polymerase II transcription genome-wide. A general factor that regulates Mediator function is the four-subunit kinase module, which contains either cyclin-dependent kinase 8 (CDK8) or CDK19. Whereas CDK8 is linked to specific signaling cascades and oncogenesis, the cellular roles of its paralog, CDK19, are poorly studied. We discovered that osteosarcoma cells (SJSA) are...

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PMID: 28416637
DOI: 10.1128/mcb.00626-16

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