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Article

Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division.

The Journal of biological chemistry - 14 Mar 2014

D'Annibale Sara, Kim Jihoon, Magliozzi Roberto, Low Teck Yew, Mohammed Shabaz, Heck Albert J R, Guardavaccaro Daniele

Abstract excerpt

TFAP4, a basic helix-loop-helix transcription factor that regulates the expression of a multitude of genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition, is up-regulated in colorectal cancer and a number of other human malignancies. We have found that, during the G2 phase of the cell division cycle, TFAP4 is targeted for proteasome-dependent degradation by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proteasome Endopeptidase Complex

Share to SKP Cullin F-Box Protein Ligases

Source

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Identifiers

PMID: 24500709
DOI: 10.1074/jbc.M114.549535
PMCID: PMC3953283

Genes

TFAP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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