Article

Alternative Cdc20 translational isoforms bypass the spindle assembly checkpoint to control mitotic arrest duration

2021-10-24

Abstract excerpt

Mitotic chromosome segregation defects activate the Spindle Assembly Checkpoint (SAC), which inhibits the APC/C co-activator Cdc20 to induce a prolonged cell cycle arrest. Once errors are corrected, the SAC is silenced thereby allowing anaphase onset and mitotic exit to proceed. However, in the presence of persistent, unresolvable errors, cells can undergo “mitotic slippage”, exiting mitosis into a tetraploid G1 s...

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Literature Corpus work: 2371f5d4-e994-5da2-b9ce-d190a685edc5
DOI: 10.1101/2021.10.24.465552

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