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Article

Dysregulation of mitotic machinery genes precedes genome instability during spontaneous pre-malignant transformation of mouse ovarian surface epithelial cells.

BMC genomics - 25 Oct 2016

Urzúa Ulises, Ampuero Sandra, Roby Katherine F, Owens Garrison A, Munroe David J

Abstract excerpt

BACKGROUND: Based in epidemiological evidence, repetitive ovulation has been proposed to play a role in the origin of ovarian cancer by inducing an aberrant wound rupture-repair process of the ovarian surface epithelium (OSE). Accordingly, long term cultures of isolated OSE cells undergo in vitro spontaneous transformation thus developing tumorigenic capacity upon extensive subcultivation. In this work, C57BL/6...

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Identifiers

PMID: 27801298
DOI: 10.1186/s12864-016-3068-5
PMCID: PMC5088517

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Source receipt: pubmed, retrieved 7 Sept 2026.

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