Article

Unveiling Genomic Rearrangements in Engineered iPSC Lines by Optical Genome Mapping

2025-05-11

Abstract excerpt

<h4>ABSTRACT</h4> We demonstrate here the use of optical genome mapping (OGM) to detect genetic alterations arising from gene editing by various technologies in human induced pluripotent stem cells (iPSCs). OGM enables an unbiased and comprehensive analysis of the entire genome, allowing the detection of genomic structural variants (SVs) of all classes with a quantitative variant allele frequency (VAF) sensitivit...

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Literature Corpus work: 99c45257-f49e-54ce-8013-296aa81f147c
DOI: 10.1101/2025.05.10.653237

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