Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway

Abstract excerpt

The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cellular metabolism and growth by coordinating nutrient resources, including cholesterol, and its aberrant activation is linked to various age-related diseases. LYCHOS is a cholesterol sensor on the lysosome and bound to the GATOR1 complex, a GTPase-activating protein for the Rag GTPase, at high cholesterol concentrations, thereby activating...

Topics

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• Calcium signaling and nucleotide metabolism
• Crystallography, X-Ray
• HEK293 Cells
• Leucine
• Mechanistic Target of Rapamycin Complex 1
• Multiprotein Complexes
• Peptidase Inhibition and Analysis
• Toxin Mechanisms and Immunotoxins

Identifiers and source

Literature Corpus work

0ab93057-5fbd-56af-bbac-f60bd08ee6d3

DOI

10.1101/2024.11.21.624772