Article

Molecular basis for ligand-gating of the human GluD1 receptor

2026-04-08

Abstract excerpt

The delta-type ionotropic glutamate receptors (iGluRs) GluD1 and GluD2 are ligand-gated ion channels that are fundamental for regulating both excitatory and inhibitory synapses. Rising evidence points to the role of GluD1 in the development of neurological diseases. However, the ultrastructure of human GluD1 (hGluD1) and the molecular basis for its ligand-gating remain unclear. Here, we define the structure of hGl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eb3eecf5-de0d-5f17-8aab-8378d9a81b14
DOI: 10.64898/2026.04.06.716743

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular basis for ligand-gating of the human GluD1 receptorDOI 10.64898/2026.04.06.716743Read

GluDs are ionotropic dopamine receptors tuned by G-proteinsSemantic proximity Read

The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region.Semantic proximity Read

Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain.Semantic proximity Read

Emerging models of glutamate receptor ion channel structure and function.Semantic proximity Read

The LGI1 protein: molecular structure, physiological functions and disruption-related seizures.Semantic proximity Read

The pathogenic S688Y mutation in the ligand-binding domain of the GluN1 subunit regulates the properties of NMDA receptors.Semantic proximity Read

An atomic interaction conserved for over 600 million years gates inhibitory neurotransmissionSemantic proximity Read

An NMDA receptor gating mechanism developed from MD simulations reveals molecular details underlying subunit-specific contributions.Semantic proximity Read

<i>GRID1/</i>GluD1 homozygous variants linked to intellectual disability and spastic paraplegia impair mGlu1/5 receptor signaling and excitatory synapsesSemantic proximity Read

Independent regulation of early trafficking of NMDA receptors by ligand-binding domains of the GluN1 and GluN2A subunitsSemantic proximity Read

Structures of partially occupied hetero-tetramers provide insight into kainate receptor activation and desensitization.Semantic proximity Read

Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling.Semantic proximity Read