Article

Anti-PSMA CAR-Engineered NK-92 Cells: An Off-the-Shelf Cell Therapy for Prostate Cancer

2020-05-15

Abstract excerpt

Prostate cancer (PCa) has become the most common tumor among males in Europe and the USA. Adoptive immunotherapy appears as a promising strategy to control the advanced stages of the disease by specific targeting the tumor, in particular through chimeric antigen receptor T (CAR-T) cell therapy. Despite the advancements of CAR-T technology in the treatment of hematological malignancies, solid tumors still represent...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99c31ab2-de9b-58f9-ab68-fef32b73ad1d
DOI: 10.20944/preprints202005.0259.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anti-PSMA CAR-Engineered NK-92 Cells: An Off-the-Shelf Cell Therapy for Prostate CancerDOI 10.20944/preprints202005.0259.v1Read

NK cells specifically TCR-dressed to kill cancer cellsSemantic proximity Read

DAP12-based activating chimeric antigen receptor for NK cell tumor immunotherapy.Semantic proximity Read

The Natural Killer Cell Line NK-92 and Its Genetic Variants: Impact on NK Cell Research and Cancer ImmunotherapySemantic proximity Read

PSMA-Specific Car-Engineered T Cells for Prostate Cancer: CD28 outperforms combined CD28-41BB “Super- stimulation”Semantic proximity Read

New approaches and prospects of immunotherapy and gene therapy for prostate cancerSemantic proximity Read

NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful DevelopmentSemantic proximity Read

CAR-NK cells with dual targeting of PD-L1 and MICA/B in human lung cancer H1299 cell tumor modelSemantic proximity Read

Androgen receptor signaling blockade enhances NK cell-mediated killing of prostate cancer cells and sensitivity to NK cell checkpoint blockadeSemantic proximity Read

PSMA-CAR-T Cells for Metastatic Castration-Resistant Prostate Cancer: An Integrated Framework for Translational OptimizationSemantic proximity Read

Induction of human cytotoxic T lymphocytes specific for prostate-specific antigenSemantic proximity Read

Reduction of the CD16−CD56bright NK Cell Subset Precedes NK Cell Dysfunction in Prostate CancerSemantic proximity Read

A multifunctional T-cell engager containing CD80 enhances prostate cancer treatmentSemantic proximity Read