Article

PSMA-Specific Car-Engineered T Cells for Prostate Cancer: CD28 outperforms combined CD28-41BB “Super- stimulation”

2020-07-22

Abstract excerpt

Despite advances in the understanding of its molecular pathophysiology, prostate cancer remains largely incurable, highlighting the need for novel therapies. We developed a chimeric antigen receptor (CAR) specific for prostate specific membrane antigen (PSMA), a glycoprotein that is overexpressed in prostate cancer, which expression involves neovasculature of several tumor entities, thus envisaging an additional a...

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Literature Corpus work: fb77e0ee-2186-5f3e-9e1f-dc44ff561a29
DOI: 10.20944/preprints202007.0520.v1

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