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NK cells specifically TCR-dressed to kill cancer cells

18 Jan 2019

Abstract excerpt

BACKGROUND: Adoptive T-cell transfer of therapeutic TCR holds great promise to specifically kill cancer cells, but relies on modifying the patient's own T cells ex vivo before injection. The manufacturing of T cells in a tailor-made setting is a long and expensive process which could be resolved by the use of universal cells. Currently, only the Natural Killer (NK) cell line NK-92 is FDA approved for universal...

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PMID: 30665853
DOI: 10.1016/j.ebiom.2019.01.031

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