Article

PSMA-CAR-T Cells for Metastatic Castration-Resistant Prostate Cancer: An Integrated Framework for Translational Optimization

2026-01-29

Abstract excerpt

<title>Abstract</title> <p> Background Metastatic castration-resistant prostate cancer (mCRPC) portends a poor prognosis and represents an area of urgent unmet clinical need. The high, specific overexpression of prostate-specific membrane antigen (PSMA) on tumor cells provides a compelling rationale for targeted immunotherapy. However, the translation of PSMA-directed chimeric antigen receptor T (CAR-T) cell th...

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Literature Corpus work: 405321dd-f0d4-5a52-9642-ba562b7d3d9e
DOI: 10.21203/rs.3.rs-8538819/v1

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