Article
DAP12-based activating chimeric antigen receptor for NK cell tumor immunotherapy.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015
Töpfer Katrin, Cartellieri Marc, Michen Susanne, Wiedemuth Ralf, Müller Nadja, Lindemann Dirk, Bachmann Michael, Füssel Monika, Schackert Gabriele, Temme Achim
Abstract excerpt
NK cells are emerging as new effectors for immunotherapy of cancer. In particular, the genetic engraftment of chimeric Ag receptors (CARs) in NK cells is a promising strategy to redirect NK cells to otherwise NK cell-resistant tumor cells. On the basis of DNAX-activation protein 12 (DAP12), a signaling adaptor molecule involved in signal transduction of activating NK cell receptors, we generated a new type of CAR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.