CAR-NK cells with dual targeting of PD-L1 and MICA/B in human lung cancer H1299 cell tumor model

Abstract excerpt

<title>Abstract</title> <p>Background Chimeric antigen receptor (CAR) engineered natural killer (NK) cells have shown their efficacy and superiority against cancer and possess the potential to become off-the-shelf immunotherapy products. Nonetheless, some challenges associated with CAR-NK cells still exist including inhibitory receptor engagement, antigen escape, and inadequate activation. Methods Given this, b...

Topics

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• Cancer Immunotherapy and Biomarkers
• CAR-T cell therapy research
• Immune Cell Function and Interaction
• Immunotherapy and Immune Responses
• Lymphoma Diagnosis and Treatment
• Nanowire Synthesis and Applications
• T-cell and B-cell Immunology
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

27649563-f6a3-54c3-988a-eb70888e0e8b

DOI

10.21203/rs.3.rs-5406191/v1