Article

Androgen receptor signaling blockade enhances NK cell-mediated killing of prostate cancer cells and sensitivity to NK cell checkpoint blockade

2023-11-17

Abstract excerpt

<h4>Background</h4> The blockade of the androgen receptor (AR) pathway is an effective treatment for prostate cancer (PCa), but many patients progress to metastatic castration-resistant prostate cancer (mCRPC). Treatments for mCRPC include AR inhibitors (ARi), chemotherapy, PARP inhibitors, and radioligands. Checkpoint inhibitor activity is limited to a small subset of MSI-H mCRPC. AR signaling modulates CD8+ T c...

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Literature Corpus work: 336bd9a4-39f3-5d47-8091-9c32c1b94cbc
DOI: 10.1101/2023.11.15.567201

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