The Therapeutic Antibody Profiler (TAP): Five Computational Developability Guidelines

Abstract excerpt

Therapeutic monoclonal antibodies (mAbs) must not only bind to their target but must also be free from 'developability issues', such as poor stability or high levels of aggregation. While small molecule drug discovery benefits from Lipinski's rule of five to guide the selection of molecules with appropriate biophysical properties, there is currently no in silico analog for antibody design. Here, we model the vari...

Topics

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• Biosimilars and Bioanalytical Methods
• Monoclonal and Polyclonal Antibodies Research
• Protein purification and stability
• RNA and protein synthesis mechanisms
• vaccines and immunoinformatics approaches
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

dcff2d14-6189-55d7-b6bf-fd33e72da374

DOI

10.1101/359141