Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning.

doi:10.1038/s41551-023-01074-6

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Article

Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning.

Nature biomedical engineering - 1 Jan 2024

Makowski Emily K, Wang Tiexin, Zupancic Jennifer M, Huang Jie, Wu Lina, Schardt John S, De Groot Anne S, Elkins Stephanie L, Martin William D, Tessier Peter M

Abstract excerpt

Antibody development, delivery, and efficacy are influenced by antibody-antigen affinity interactions, off-target interactions that reduce antibody bioavailability and pharmacokinetics, and repulsive self-interactions that increase the stability of concentrated antibody formulations and reduce their corresponding viscosity. Yet identifying antibody variants with optimal combinations of these three types of...

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PMID: 37666923
DOI: 10.1038/s41551-023-01074-6
PMCID: PMC10842909

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