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Article

Intrinsic physicochemical profile of marketed antibody-based biotherapeutics

9 Sept 2021

Abstract excerpt

Feeding biopharma pipelines with biotherapeutic candidates that possess desirable developability profiles can help improve the productivity of biologic drug discovery and development. Here, we have derived an in silico profile by analyzing computed physicochemical descriptors for the variable regions (Fv) found in 77 marketed antibody-based biotherapeutics. Fv regions of these biotherapeutics demonstrate...

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PMID: 34504010
DOI: 10.1073/pnas.2020577118

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