Article
The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice.
Hepatology (Baltimore, Md.) - 1 Nov 2014
Pawlak Michal, Baugé Eric, Bourguet William, De Bosscher Karolien, Lalloyer Fanny, Tailleux Anne, Lebherz Corinna, Lefebvre Philippe, Staels Bart
Abstract excerpt
UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and strongly associated with central obesity, dyslipidemia, and insulin resistance. According to the multiple-hit model of NAFLD pathogenesis, lipid accumulation drives nonalcoholic steatohepatitis (NASH) initiation by triggering oxidative stress, lipotoxicity, and subsequent activation of hepatic inflammatory responses that may...
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