Hepatic JNK-mediated bile acid homeostasis regulates liver cancer through PPARα

Abstract excerpt

<h4>ABSTRACT</h4> cJun NH 2 -terminal kinase (JNK) inhibition has been suggested as a potential treatment for insulin resistance and steatosis through activation of the transcription factor PPARα. However, the long-term consequences have not been evaluated. We found that hepatic JNK deficiency alters bile acid and cholesterol metabolism, resulting in hepatic expression of FGF15 and activation of ERK in cholangio...

Topics

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• Adipokines, Inflammation, and Metabolic Diseases
• Adipose Tissue and Metabolism
• Diet, Metabolism, and Disease
• Liver Disease Diagnosis and Treatment
• Peroxisome Proliferator-Activated Receptors

Identifiers and source

Literature Corpus work

379bd62c-6041-5f4d-a502-bff01e0e646e

DOI

10.1101/783761