Back to search

Article

<i>Plasmodium</i> killing and antimicrobial lineal or cyclic-peptides computationally targeted the circumsporozoite CSP protein

2025-10-01

Abstract excerpt

The RT39 a mphipathic l ineal- p eptide (ALP), described as the faster membranolytic-killer of circumsporozoite Plasmodium falciparum (Aguirre-Botero et al , 2024), computationally predicted the highest affinities to the external c ircum s porozoite p rotein (CSP), compared to other described ALPs. Additional computational co-cyclizations of CSP/ALPs generated CSP/cycRT39 cyclic-conformers predicting the h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
99b929e2-b020-5986-a21d-20f850fa9b38
DOI
10.1101/2025.09.30.679691
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<i>Plasmodium</i> killing and antimicrobial lineal or cyclic-peptides computationally targeted the circumsporozoite CSP proteinDOI 10.1101/2025.09.30.679691
<i>Plasmodium</i> circumsporozoites targeted by RFdiffusion / cyclic-peptidesSemantic proximity
Identification of potent and selective <i>N</i> -myristoyltransferase inhibitors of <i>Plasmodium vivax</i> liver stage hypnozoites and schizontsSemantic proximity
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infectionsSemantic proximity
Aryl N-acetamide compounds exert antimalarial activity by acting as agonists of rhomboid protease <i>Pf</i> ROM8 and cation channel <i>Pf</i> CSC1Semantic proximity
<i>In silico</i> , biochemical, and <i>in vitro</i> analysis of silvestrol binding to the DEAD box RNA helicase eIF4A reveals broad anti-pathogen potential of rocaglates across the eukaryotic tree of lifeSemantic proximity
Discovery of tREP-18, a novel class of <i>t</i> RNA encoded peptide with potent leishmanicidal activitySemantic proximity
Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases.Semantic proximity
Computational modeling of cyclotides as antimicrobial agents against Neisseria gonorrhoeae PorB porin protein: integration of docking, immune, and molecular dynamics simulationsSemantic proximity
Selective Bias Virtual Screening for Discovery of Promising Antimalarial Candidates targeting Plasmodium N-MyristoyltransferaseSemantic proximity
Physical–Chemical Approach to Identify Local Structural Determinants of Molecular Mechanisms: Case Study of Antimalarial Drug Pyronaridine and Crystal-Growth InhibitionSemantic proximity
Identification, Characterization and Synthesis of Natural Parasitic Cysteine Protease Inhibitors – More Potent Falcitidin AnalogsSemantic proximity
Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeatsSemantic proximity
Select a neighboring publication to make it the new centre.