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Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats

13 Jan 2022

Abstract excerpt

Malaria is a global health burden, with Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) responsible for the majority of infections worldwide. Circumsporozoite protein (CSP) is the most abundant protein on the surface of Plasmodium sporozoites, and antibodies targeting the central repeat region of CSP can prevent parasite infection. Although much has been uncovered about the molecular basis of antibody...

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PMID: 35023832
DOI: 10.7554/elife.72908

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