Article

Identification, Characterization and Synthesis of Natural Parasitic Cysteine Protease Inhibitors – More Potent Falcitidin Analogs

2021-10-30

Abstract excerpt

<h4>ABSTRACT</h4> Protease inhibitors represent a promising therapeutic option for the treatment of parasitic diseases such as malaria and human African trypanosomiasis. Falcitidin was the first member of a new class of inhibitors of falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum . Using a metabolomics dataset of 25 Chitinophaga strains for molecular networking enabled identifica...

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Literature Corpus work: 427c33c9-1ab0-537a-986f-46bc2d09ea9d
DOI: 10.1101/2021.10.30.466580

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