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Article

Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases.

The EMBO journal - 3 Apr 2018

Mukherjee Budhaditya, Tessaro Francesca, Vahokoski Juha, Kursula Inari, Marq Jean-Baptiste, Scapozza Leonardo, Soldati-Favre Dominique

Abstract excerpt

Toxoplasma gondii aspartyl protease 3 (TgASP3) phylogenetically clusters with Plasmodium falciparum Plasmepsins IX and X (PfPMIX, PfPMX). These proteases are essential for parasite survival, acting as key maturases for secreted proteins implicated in invasion and egress. A potent antimalarial peptidomimetic inhibitor (49c) originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX To...

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Identifiers

PMID: 29519896
DOI: 10.15252/embj.201798047
PMCID: PMC5881632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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