Structural variants shape the genomic landscape and clinical outcome of multiple myeloma

Abstract excerpt

Deciphering genomic architecture is key to identifying novel disease drivers and understanding the mechanisms underlying myeloma initiation and progression. In this work, using the CoMMpass dataset, we show that structural variants (SV) occur in a nonrandom fashion throughout the genome with an increased frequency in the t(4;14), RB1, or TP53 mutated cases and reduced frequency in t(11;14) cases. By mapping sites...

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• Multiple Myeloma Research and Treatments
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways