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Revealing the Impact of Structural Variants in Multiple Myeloma

15 Sept 2020

Abstract excerpt

Abstract The landscape of structural variants (SV) in multiple myeloma remains poorly understood. Here, we performed comprehensive analysis of SVs in a large cohort of 752 patients with multiple myeloma by low-coverage long-insert whole-genome sequencing. We identified 68 SV hotspots involving 17 new candidate driver genes, including the therapeutic targets BCMA (TNFRSF17), SLAM7, and MCL1. Catastrophic complex...

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Share to Glycosylation and Glycoproteins Research
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PMID: 33392515
DOI: 10.1158/2643-3230.bcd-20-0132

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