Article

Impairment of methylglyoxal detoxification systems causes mitochondrial dysfunction and schizophrenia-like behavioral deficits

2020-07-09

Abstract excerpt

Methylglyoxal (MG) is a cytotoxic α -dicarbonyl byproduct of glycolysis. Our bodies have several bio-defense systems to detoxify MG, including an enzymatic system by glyoxalase (GLO) 1 and a scavenge system by vitamin B6 (VB6). We know a population of patients with schizophrenia impaired MG detoxification systems. However, the molecular mechanism connecting them remains poorly understood. We created a novel mouse...

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Literature Corpus work: 99ab0885-4844-506e-ab64-77d2551950f2
DOI: 10.1101/2020.07.08.192906

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