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Article

Genetic vitamin B6 deficiency exacerbates alcohol behavioral responses, metabolism, and toxicity in Drosophila.

Human molecular genetics - 15 Apr 2026

Wang Benjamin, Fu Wenqin, Ueda Atsushi, Shah Hardik, Wu Chun-Fang, Chi Wanhao, Zhuang Xiaoxi

Abstract excerpt

Alcohol abuse is a leading cause of preventable deaths. Alcohol affects brain function and metabolism, including GABA transmission and vitamin B6 (VB6) levels. VB6 is a cofactor for GABA synthesis and degradation; however, the interaction between VB6 deficiency and alcohol consumption remains unknown. We utilized dietary VB6 manipulations and Drosophila models with mutations in pyridox(am)ine-5'-phosphate oxidase...

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Identifiers

PMID: 42017538
DOI: 10.1093/hmg/ddag032
PMCID: PMC13100819

Genes

PNPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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