Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glyoxalase System in the Progression of Skin Aging and Skin Malignancies.

International journal of molecular sciences - 30 Dec 2020

Yumnam Silvia, Subedi Lalita, Kim Sun Yeou

Abstract excerpt

Dicarbonyl compounds, including methylglyoxal (MGO) and glyoxal (GO), are mainly formed as byproducts of glucose metabolism. The main glyoxalase system consists of glyoxalase I and II (Glo1 and Glo2) and is the main enzyme involved in the detoxification of dicarbonyl stress, which occurs as an accumulation of MGO or GO due to decreased activity or expression of Glo1. Dicarbonyl stress is a major cause of cellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Susceptibility
Share to Gene Expression Regulation
Share to Lactoylglutathione Lyase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pyruvaldehyde

Share to Skin Aging

Share to Skin Neoplasms

Share to Thiolester Hydrolases

Share to Wound Healing

Source

Open in PubMed Open full text

Identifiers

PMID: 33396745
DOI: 10.3390/ijms22010310
PMCID: PMC7794849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glyoxalase System in the Progression of Skin Aging and Skin Malignancies.PMID 33396745Read ↗

The Human Glyoxalase Gene Family in Health and DiseaseSemantic proximity Read ↗

Molecular Assessment of Methylglyoxal-Induced Toxicity and Therapeutic Approaches in Various Diseases: Exploring the Interplay with the Glyoxalase SystemSemantic proximity Read ↗

Hallmarks of Skin Aging: UpdateSemantic proximity Read ↗

Focus on the Contribution of Oxidative Stress in Skin AgingSemantic proximity Read ↗

Dicarbonyl-induced accelerated aging in vitro in human skin fibroblasts.Semantic proximity Read ↗

Bacterial Responses to Glyoxal and Methylglyoxal: Reactive Electrophilic SpeciesSemantic proximity Read ↗

Oxidative Stress and Its Role in Skin DiseaseSemantic proximity Read ↗

Glyoxal induces DNA-Protein Crosslinking in CellsSemantic proximity Read ↗

Identification of glyoxalase 1 polymorphisms associated with enzyme activity.Semantic proximity Read ↗

An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivoSemantic proximity Read ↗

Oxidative Stress and Human Skin Connective Tissue AgingSemantic proximity Read ↗

Glyoxalases in Urological MalignanciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.