Article
Methylglyoxal-mediated anxiolysis involves increased protein modification and elevated expression of glyoxalase 1 in the brain.
Journal of neurochemistry - 1 Jun 2010
Hambsch Boris, Chen Bud-Gen, Brenndörfer Julia, Meyer Melanie, Avrabos Charilaos, Maccarrone Giuseppina, Liu Ray H, Eder Matthias, Turck Christoph W, Landgraf Rainer
Abstract excerpt
Methylglyoxal (MG) is a highly reactive metabolite that forms adducts with basic amino acid side chains in proteins. MG is degraded by glyoxalase1 (GLO1), an enzyme shown to be differentially expressed in several mouse models of anxiety-related behavior. As yet, molecular mechanisms by which altered GLO1 expression influences emotionality have not been elucidated. Here we report that both MG concentration and...
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