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Genetic analysis of the glyoxalase system in schizophrenia.

Progress in neuro-psychopharmacology & biological psychiatry - 3 Jun 2015

Bangel Fabian N, Yamada Kazuo, Arai Makoto, Iwayama Yoshimi, Balan Shabeesh, Toyota Tomoko, Iwata Yasuhide, Suzuki Katsuaki, Kikuchi Mitsuru, Hashimoto Tasuku, Kanahara Nobuhisa, Mori Norio, Itokawa Masanari, Stork Oliver, Yoshikawa Takeo

Abstract excerpt

Recent reports suggest that carbonyl stress might affect a subset of schizophrenia patients suffering from severe symptoms. Carbonyl stress protection is achieved by the glyoxalase system consisting of two enzymes, glyoxalase 1 and 2, which in humans are encoded by the genes GLO1 and HAGH, respectively. Glyoxalase 1 and 2 catalyze the detoxification of reactive alpha-oxoaldehydes such as glyoxal and...

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Identifiers

PMID: 25645869
DOI: 10.1016/j.pnpbp.2015.01.014

Genes

HAGH
GLO1

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