Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Co-evolutionary analysis of domains in interacting proteins reveals insights into domain-domain interactions mediating protein-protein interactions.

Journal of molecular biology - 29 Sept 2006

Jothi Raja, Cherukuri Praveen F, Tasneem Asba, Przytycka Teresa M

Abstract excerpt

Recent advances in functional genomics have helped generate large-scale high-throughput protein interaction data. Such networks, though extremely valuable towards molecular level understanding of cells, do not provide any direct information about the regions (domains) in the proteins that mediate the interaction. Here, we performed co-evolutionary analysis of domains in interacting proteins in order to understand...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COP-Coated Vesicles
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTPase-Activating Proteins

Share to Karyopherins

Share to Nucleocytoplasmic Transport Proteins

Share to Protein Interaction Mapping

Share to Proton-Translocating ATPases

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 16949097
DOI: 10.1016/j.jmb.2006.07.072
PMCID: PMC1618801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Co-evolutionary analysis of domains in interacting proteins reveals insights into domain-domain interactions mediating protein-protein interactions.PMID 16949097Read ↗

Prediction and discovery of protein-protein direct interactions and stable complexes based on gene co-expression and co-evolutionSemantic proximity Read ↗

The evolution of domain arrangements in proteins and interaction networks.Semantic proximity Read ↗

Identification of Protein-Protein Interactions by Detecting Correlated Mutation at the Interface.Semantic proximity Read ↗

The human protein coevolution network.Semantic proximity Read ↗

Interactome evolution: insights from genome-wide analyses of protein-protein interactions.Semantic proximity Read ↗

Conservation and coevolution determine evolvability of different classes of disordered residues in human intrinsically disordered proteins.Semantic proximity Read ↗

The origins of the evolutionary signal used to predict protein-protein interactions.Semantic proximity Read ↗

Structure, function, and evolution of transient and obligate protein-protein interactions.Semantic proximity Read ↗

Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions.Semantic proximity Read ↗

Emerging methods in protein co-evolution.Semantic proximity Read ↗

Yeast protein-protein interaction binding sites: prediction from the motif-motif, motif-domain and domain-domain levels.Semantic proximity Read ↗

Systematic domain-based aggregation of protein structures highlights DNA-, RNA-, and other ligand-binding positionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.