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Article

AAV-Nrf2 Promotes Protection and Recovery in Animal Models of Oxidative Stress.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2017

Liang Katharine J, Woodard Kenton T, Weaver Mark A, Gaylor John Paul, Weiss Ellen R, Samulski R Jude

Abstract excerpt

NRF2 is a transcription factor that drives antioxidant gene expression in multiple organ systems. We hypothesized that Nrf2 overexpression could be therapeutically applied toward diseases in which redox homeostasis is disrupted. In this study, adeno-associated virus (AAV)-Nrf2 was tested in a mouse model of acute acetaminophen-induced liver toxicity and successfully conferred protection from hepatotoxicity,...

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Source

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Identifiers

PMID: 28253482
DOI: 10.1016/j.ymthe.2016.12.016
PMCID: PMC5363194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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