Article

TBX5 dosage governs ventricular cardiomyocyte maturation, specialization and dedifferentiation <i>in vivo</i>

2026-04-15

Abstract excerpt

Variation in transcription factor (TF) activity modulates traits and disease susceptibility, yet how such variation translates into cellular phenotype and organ function in vivo is not well established. We utilized AAV-mediated gene delivery to express the dosage-sensitive TF TBX5 across a physiologically plausible range in postnatal ventricular cardiomyocytes. Transcriptomic profiling revealed that TBX5 dosage-d...

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Literature Corpus work: 9b2e3330-ff72-576e-8d4d-21e98395123e
DOI: 10.64898/2026.04.13.718086

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