Article

The impact of identity-by-descent on fitness and disease in natural and domesticated <i>Canid</i> populations

2020-11-17

Abstract excerpt

Domestic dogs have experienced population bottlenecks, recent inbreeding, and strong artificial selection. These processes have simplified the genetic architecture of complex traits, allowed deleterious variation to persist, and increased both identity-by-descent (IBD) segments and runs of homozygosity (ROH). As such, dogs provide an excellent model for examining how these evolutionary processes influence disease....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99663885-9658-574d-9672-4617f91c894e
DOI: 10.1101/2020.11.16.385443

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The impact of identity-by-descent on fitness and disease in natural and domesticated <i>Canid</i> populationsDOI 10.1101/2020.11.16.385443Read

The impact of identity by descent on fitness and disease in dogs.Semantic proximity Read

Fine-scale resolution and analysis of runs of homozygosity in domestic dogsSemantic proximity Read

Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and healthSemantic proximity Read

Genotypic and phenotypic consequences of domestication in dogsSemantic proximity Read

Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs.Semantic proximity Read

Determinants of de novo mutations in extended pedigrees of 43 dog breedsSemantic proximity Read

Joint dog and wolf genealogies reveal the evolution of the canine genomeSemantic proximity Read

Genetic prevalence and clinical relevance of canine Mendelian disease variants in over one million dogsSemantic proximity Read

Evolutionary genomics of dog domestication.Semantic proximity Read

Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture.Semantic proximity Read

Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait mapping.Semantic proximity Read

Genomic analyses of modern dog breeds.Semantic proximity Read