Article
Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2016
Marsden Clare D, Ortega-Del Vecchyo Diego, O'Brien Dennis P, Taylor Jeremy F, Ramirez Oscar, Vilà Carles, Marques-Bonet Tomas, Schnabel Robert D, Wayne Robert K, Lohmueller Kirk E
Abstract excerpt
Population bottlenecks, inbreeding, and artificial selection can all, in principle, influence levels of deleterious genetic variation. However, the relative importance of each of these effects on genome-wide patterns of deleterious variation remains controversial. Domestic and wild canids offer a powerful system to address the role of these factors in influencing deleterious variation because their history is...
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