Article

Determinants of de novo mutations in extended pedigrees of 43 dog breeds

2024-06-05

Abstract excerpt

Intensive breeding of dogs has had dramatic effects on genetic variants underlying phenotypes. To investigate whether this also affected mutation rates, we deep-sequenced pedigrees from 43 different dog breeds representing 404 trios. We find that the mutation rate is remarkably stable across breeds and is predominantly influenced by variation in parental ages. The effect of paternal age per year on mutation rates...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1bb1fc26-cd60-585a-b131-45686d2337fa
DOI: 10.1101/2024.06.04.596747

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Determinants of de novo mutations in extended pedigrees of 43 dog breedsDOI 10.1101/2024.06.04.596747Read

Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and healthSemantic proximity Read

The impact of identity-by-descent on fitness and disease in natural and domesticated <i>Canid</i> populationsSemantic proximity Read

Germline methylation patterns determine the distribution of recombination events in the dog genome.Semantic proximity Read

Evolutionary genomics of dog domestication.Semantic proximity Read

The impact of identity by descent on fitness and disease in dogs.Semantic proximity Read

Genomic Analyses Reveal the Influence of Geographic Origin, Migration, and Hybridization on Modern Dog Breed Development.Semantic proximity Read

Genetic prevalence and clinical relevance of canine Mendelian disease variants in over one million dogsSemantic proximity Read

Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture.Semantic proximity Read

Sex differences in PRDM9-independent fine-scale recombination patternsSemantic proximity Read

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.Semantic proximity Read

Fine-scale resolution and analysis of runs of homozygosity in domestic dogsSemantic proximity Read

Genomic diversity and population structure of the Leonberger dog breed.Semantic proximity Read