Article
The impact of identity by descent on fitness and disease in dogs.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2021
Mooney Jazlyn A, Yohannes Abigail, Lohmueller Kirk E
Abstract excerpt
Domestic dogs have experienced population bottlenecks, recent inbreeding, and strong artificial selection. These processes have simplified the genetic architecture of complex traits, allowed deleterious variation to persist, and increased both identity-by-descent (IBD) segments and runs of homozygosity (ROH). As such, dogs provide an excellent model for examining how these evolutionary processes influence...
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