Article

β-catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia

2022-07-09

Abstract excerpt

<h4>ABSTRACT</h4> Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the evolution of T-Acute Lymphoblastic Leukemia (T-ALL) patients and its involvement in therapy resistance. We have identified a specific gene signature that is directly regulated by...

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Literature Corpus work: 995b2342-4859-5aca-936e-43a5de6d60d8
DOI: 10.1101/2022.07.07.499249

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