RNA sequencing unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications.

doi:10.3324/haematol.2015.139410

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Article

RNA sequencing unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications.

Haematologica - 1 Aug 2016

Gianfelici Valentina, Chiaretti Sabina, Demeyer Sofie, Di Giacomo Filomena, Messina Monica, La Starza Roberta, Peragine Nadia, Paoloni Francesca, Geerdens Ellen, Pierini Valentina, Elia Loredana, Mancini Marco, De Propris Maria Stefania, Apicella Valerio, Gaidano Gianluca, Testi Anna Maria, Vitale Antonella, Vignetti Marco, Mecucci Cristina, Guarini Anna, Cools Jan, Foà Robin

Abstract excerpt

Despite therapeutic improvements, a sizable number of patients with T-cell acute lymphoblastic leukemia still have a poor outcome. To unravel the genomic background associated with refractoriness, we evaluated the transcriptome of 19 cases of refractory/early relapsed T-cell acute lymphoblastic leukemia (discovery cohort) by performing RNA-sequencing on diagnostic material. The incidence and prognostic impact of...

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PMID: 27151993
DOI: 10.3324/haematol.2015.139410
PMCID: PMC4967573

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