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Article

Wnt/?-catenin-pathway as a molecular target for future anti-cancer therapeutics

1 Jan 2004

Abstract excerpt

Conventional chemotherapeutic drugs used for the treatment of cancer patients in advanced stages have yielded only limited benefit, regarding survival time not to mention cure of the patients. To improve the clinical outcome of cancer, agents aimed at novel molecular targets are required. Colorectal and many other cancers are caused by hyperactivity of the Wnt/beta-catenin signaling pathway that results in...

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PMID: 15472907
DOI: 10.1002/ijc.20609

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