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Article

Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia

4 Jul 2014

Abstract excerpt

While childhood acute lymphoblastic leukaemia (ALL) is now highly curable, the dismal prognosis for children who relapse warrants novel therapeutic approaches. Previously, using an integrated genomic analysis of matched diagnosis-relapse paired samples, we identified overactivation of the Wnt pathway as a possible mechanism of recurrence. To validate these findings and document whether Wnt inhibition may...

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Share to Acute Lymphoblastic Leukemia research
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PMID: 24995804
DOI: 10.1111/bjh.13011

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