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Article

Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia

14 Mar 2014

Abstract excerpt

WNT signaling has been implicated in the regulation of hematopoietic stem cells and plays an important role during T-cell development in thymus. Here we investigated WNT pathway activation in childhood T-cell acute lymphoblastic leukemia (T-ALL) patients. To evaluate the potential role of WNT signaling in T-cell leukomogenesis, we performed expression analysis of key components of WNT pathway. More than 85% of...

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PMID: 24632884
DOI: 10.1038/bcj.2014.12

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