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Article

β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL.

Blood - 1 Aug 2013

Kaveri Deepika, Kastner Philippe, Dembélé Doulaye, Nerlov Claus, Chan Susan, Kirstetter Peggy

Abstract excerpt

Wnt signaling is important for T-cell differentiation at the early CD4(-)CD8(-) stage and is subsequently downregulated with maturation. To assess the importance of this downregulation, we generated a mouse line (R26-βcat) in which high levels of active β-catenin are maintained throughout T-cell development. Young R26-βcat mice show a differentiation block at the CD4(+)CD8(+) double-positive (DP) stage. These DP...

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Share to beta Catenin
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Share to Receptors, Notch

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Source

Identifiers

PMID: 23801632
DOI: 10.1182/blood-2012-12-471904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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