Article

Patterns and Mechanisms of Sex Ratio Distortion in the Collaborative Cross Mouse Mapping Population

2021-06-23

Abstract excerpt

<h4>ABSTRACT</h4> In species with single-locus, chromosome-based mechanisms of sex determination, the laws of segregation predict an equal ratio of females to males at birth. Here, we show that departures from this Mendelian expectation are commonplace in the 8-way recombinant inbred Collaborative Cross (CC) mouse population. More than one-third of CC strains exhibit significant sex ratio distortion (SRD) at wean...

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Literature Corpus work: 99437798-9bfc-5f86-bc5c-8f37c53c997d
DOI: 10.1101/2021.06.23.449644

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