Article
A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.
PLoS genetics - 1 Feb 2015
Didion John P, Morgan Andrew P, Clayshulte Amelia M-F, Mcmullan Rachel C, Yadgary Liran, Petkov Petko M, Bell Timothy A, Gatti Daniel M, Crowley James J, Hua Kunjie, Aylor David L, Bai Ling, Calaway Mark, Chesler Elissa J, French John E, Geiger Thomas R, Gooch Terry J, Garland Theodore, Harrill Alison H, Hunter Kent, McMillan Leonard, Holt Matt, Miller Darla R, O'Brien Deborah A, Paigen Kenneth, Pan Wenqi, Rowe Lucy B, Shaw Ginger D, Simecek Petr, Sullivan Patrick F, Svenson Karen L, Weinstock George M, Threadgill David W, Pomp Daniel, Churchill Gary A, Pardo-Manuel de Villena Fernando
Abstract excerpt
Significant departures from expected Mendelian inheritance ratios (transmission ratio distortion, TRD) are frequently observed in both experimental crosses and natural populations. TRD on mouse Chromosome (Chr) 2 has been reported in multiple experimental crosses, including the Collaborative Cross (CC). Among the eight CC founder inbred strains, we found that Chr 2 TRD was exclusive to females that were...
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