Article
Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross.
Genetics - 1 Jun 2017
Shorter John R, Odet Fanny, Aylor David L, Pan Wenqi, Kao Chia-Yu, Fu Chen-Ping, Morgan Andrew P, Greenstein Seth, Bell Timothy A, Stevans Alicia M, Feathers Ryan W, Patel Sunny, Cates Sarah E, Shaw Ginger D, Miller Darla R, Chesler Elissa J, McMillian Leonard, O'Brien Deborah A, Villena Fernando Pardo-Manuel de
Abstract excerpt
The goal of the Collaborative Cross (CC) project was to generate and distribute over 1000 independent mouse recombinant inbred strains derived from eight inbred founders. With inbreeding nearly complete, we estimated the extinction rate among CC lines at a remarkable 95%, which is substantially higher than in the derivation of other mouse recombinant inbred populations. Here, we report genome-wide allele...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Chromosomes
- Crosses, Genetic
- Female
- Haplotypes
- Inbreeding
- Infertility, Male
- Male